Tg(tetO-EGFR*delta19)11Hev
Transgene Detail

Summary

• Symbol: Tg(tetO-EGFR*delta19)11Hev
• Name: transgene insertion 11, Harold E Varmus
• MGI ID: MGI:3690457
• Synonyms: DEL11, EGFR^{deltaL747-S752}, TetO-EGFR^{deltaL747-S752}
• Transgene: Tg(tetO-EGFR*delta19)11Hev Location: unknown
• Alliance: Tg(tetO-EGFR*delta19)11Hev page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A mutant human epidermal growth factor receptor cDNA lacking the segment encoded by exon 19 was cloned between the tetracycline-responsive element and an intron and polyadenylation signal from the mouse protamine 1 gene. Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) protein under the control of a tissue-specific promoter can be induced to express the mutant EGFR in tissues or cell types of interest by administration/withdrawal of doxycycline. (J:109092)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO-EGFR*delta19)11Hev

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Line 9 was also generated.

References

• Original: J:109092 Politi K, et al., Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev. 2006 Jun 1;20(11):1496-510
• All: 5 reference(s)