Tg(Myh6-Tnnt2*R92Q)2Lnwd
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnnt2*R92Q)2Lnwd
• Name: transgene insertion 2, Leslie A Leinwand
• MGI ID: MGI:3692450
• Synonyms: 67%, R92Q, R92Q-Myc
• Transgene: Tg(Myh6-Tnnt2*R92Q)2Lnwd Location: unknown
• Alliance: Tg(Myh6-Tnnt2*R92Q)2Lnwd page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tnnt2*R92Q)2Lnwd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnnt2 (MGI:104597)	Transgene codes for a protein with an arginine to glutamine mutation.

• Mutation details: This transgene expresses a mouse Tnnt2 gene, with codon 92 mutated to encode an glutamine instead of the arginine and an 11-amino acid c-myc epitope added to the 5' end of the coding region, under the control of a rat alpha-myosin heavy chain promoter. This line expresses 67% of the total Tnnt2 as the mutant transgenic form. (J:56911)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:56911 Tardiff JC, et al., Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. J Clin Invest. 1999 Aug;104(4):469-81
• All: 14 reference(s)