Tg(APOE-ABCA1)30Ssf
Transgene Detail
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Symbol: |
Tg(APOE-ABCA1)30Ssf |
Name: |
transgene insertion 30, Silvia Santamarina-Fojo |
MGI ID: |
MGI:3696684 |
Synonyms: |
ABCA1-Tg, hABCA1-A, hABCA1-Tg, hABCA1-tg 30c |
Transgene: |
Tg(APOE-ABCA1)30Ssf Location: unknown
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Alliance: |
Tg(APOE-ABCA1)30Ssf page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(APOE-ABCA1)30Ssf expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
ABCA1 (19) |
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Mutation details: The transgene consists of the human apoE promoter, the human ABCA1 cDNA, the poly(A) signal from the human apoE gene, and the hepatic and macrophage control regions of the apoE/apoC-I locus. Northern blot hybridization analysis and densitometric scanning demonstrated a four-fold increase in encoded mRNA in the liver and a three-fold increase in macrophages. The expressed protein was identified in both mouse liver and macrophage cell extracts by western blotting.
(J:70494)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:70494 Vaisman BL, et al., ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. J Clin Invest. 2001 Jul;108(2):303-9 |
All: |
3 reference(s) |
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