Alkal2 MGI Mouse Gene Detail - MGI:3697448

Symbol

Alkal2
Name

ALK and LTK ligand 2
Synonyms

6230419C23Rik, Augalpha, Augmentor alpha, Fam150b

Feature Type

protein coding gene
IDs

MGI:3697448
NCBI Gene: 100294583
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:30934323-30943855 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 13.00 cM
Mapping Data

1 experiment

SNPs within 2kb

269 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3697448	protein coding gene	Chr12:30934321-30943855 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019653	protein coding gene	Chr12:28802749-28812418 (+)
A/J	MGP_AJ_G0019620	protein coding gene	Chr12:27996558-28006226 (+)
AKR/J	MGP_AKRJ_G0019591	protein coding gene	Chr12:28899138-28908806 (+)
BALB/cJ	MGP_BALBcJ_G0019597	protein coding gene	Chr12:28240384-28250052 (+)
C3H/HeJ	MGP_C3HHeJ_G0019401	protein coding gene	Chr12:28758246-28767896 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020044	protein coding gene	Chr12:29696261-29707627 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017669	protein coding gene	Chr12:27317955-27327457 (+)
CAST/EiJ	MGP_CASTEiJ_G0018956	protein coding gene	Chr12:23764400-23773964 (+)
CBA/J	MGP_CBAJ_G0019372	protein coding gene	Chr12:30669017-30678685 (+)
DBA/2J	MGP_DBA2J_G0019486	protein coding gene	Chr12:27831543-27841194 (+)
FVB/NJ	MGP_FVBNJ_G0019477	protein coding gene	Chr12:27629582-27639235 (+)
LP/J	MGP_LPJ_G0019556	protein coding gene	Chr12:28891517-28901459 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019512	protein coding gene	Chr12:30294297-30303932 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020084	protein coding gene	Chr12:28419266-28428905 (+)
PWK/PhJ	MGP_PWKPhJ_G0018723	protein coding gene	Chr12:22570112-22579678 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018511	protein coding gene	Chr12:23041190-23050666 (+)
WSB/EiJ	MGP_WSBEiJ_G0019007	protein coding gene	Chr12:28656734-28666393 (+)

Human Ortholog

ALKAL2, ALK and LTK ligand 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALKAL2, ALK and LTK ligand 2
Synonyms

AUGA, FAM150B, PRO1097, RGPG542
Links

HGNC:27683

NCBI Gene ID: 285016

neXtProt AC: NX_Q6UX46

UniProt: Q6UX46
Chr Location

2p25.3; chr2:279558-288851 (-) GRCh38

MGI Vertebrate Homology

Alkal2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ALKAL2
Gene Tree

Alkal2

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Phenotype Summary

30 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous deletion of this gene results in slow postnatal weight gain, thin body, decreased adiposity, and leanness coupled to increased energy expenditure and respiratory exchange ratio, hyperactivity, improved glucose tolerance and sensitivity to insulin, and decreased susceptibility to diet-induced obesity.

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All GO Annotations

25
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

13
cDNA Data

3
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase alkal2

ZFIN alkal2a, alkal2b

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All Sequences

30
RefSeq

4
UniProt

1
CCDS

CCDS49044.1

Ensembl

ENSMUSG00000054204 (Evidence)
NCBI Gene

100294583

			Length	Strain/Species	Flank
genomic	100294583	NCBI Gene Model \| MGI Sequence Detail	9533	C57BL/6J	± kb
transcript	NM_001159743	RefSeq \| MGI Sequence Detail	1509	C57BL/6
polypeptide	Q80UG6	UniProt \| EBI \| MGI Sequence Detail	151	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032753 ALK and LTK ligand 2

(term hierarchy)
InterPro Domains

IPR029364 ALK and LTK ligand 1/2

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All nucleic 4

cDNA 3

Primer pair 1

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MGI:5897450

Summaries

All 24

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 5
Earliest

J:216664 Zhang H, et al., Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15741-5
Latest

J:338243 Christova T, et al., LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity. EMBO Rep. 2023 Jul 5;24(7):e56937

TSS for Alkal2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113090	Chr12:30934264-30934271 (+)	-55 bp
Tssr113091	Chr12:30934320-30934325 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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