Tg(Lck-cre)I540Jxm
Transgene Detail

Summary

• Symbol: Tg(Lck-cre)I540Jxm
• Name: transgene insertion I540, Jamey Marth
• MGI ID: MGI:3701502
• Transgene: Tg(Lck-cre)I540Jxm Location: unknown
• Alliance: Tg(Lck-cre)I540Jxm page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Lck-cre)I540Jxm expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lck (MGI:96756)

• Mutation details: The Cre recombinase coding sequence, modified by addition of a Kozak consensus translation start sequence and nuclear localization signals, was inserted into the p1017 expression vector between the thymocyte-specific, mouse proximal Lck promoter and most of the human growth hormone gene, extending from within exon 1 through the polyadenylation signal. Cre recombinase activity is restricted to thymocytes; evidence of activity in spleen is attributed to the presence of thymus-derived T lymphocytes. (J:67674, J:81268)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lck (mouse) Summary of all recombinase alleles driven by Lck. Alliance mouse Lck gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:67674 Hennet T, et al., T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12070-4
• All: 18 reference(s)