Rnaset2b MGI Mouse Gene Detail - MGI:3702087

Symbol

Rnaset2b
Name

ribonuclease T2B

Feature Type

protein coding gene
IDs

MGI:3702087
NCBI Gene: 68195
Alliance

gene page

Sequence Map

Chr17:7246259-7265592 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 4.57 cM
Mapping Data

1 experiment

SNPs within 2kb

275 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3702087	protein coding gene	Chr17:7238033-7278698 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023127	protein coding gene	Chr17:5569937-5614152 (-)
A/J	MGP_AJ_G0023089	protein coding gene	Chr17:4401382-4440824 (+)
AKR/J	MGP_AKRJ_G0023060	protein coding gene	Chr17:5268345-5306803 (-)
BALB/cJ	MGP_BALBcJ_G0023090	protein coding gene	Chr17:4261936-4288227 (+)
C3H/HeJ	MGP_C3HHeJ_G0022851	protein coding gene	Chr17:4349514-4393178 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023540	protein coding gene	Chr17:5835231-5870477 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021069	protein coding gene	Chr17:8706929-8737866 (+)
CAST/EiJ	MGP_CASTEiJ_G0022374	protein coding gene	Chr17:5514960-5551456 (-)
CBA/J	MGP_CBAJ_G0022830	protein coding gene	Chr17:6036846-6081896 (-)
DBA/2J	MGP_DBA2J_G0022957	protein coding gene	Chr17:4161041-4197422 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0023034	protein coding gene	Chr17:5390960-5428406 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022945	protein coding gene	Chr17:4435251-4604482 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023564	protein coding gene	Chr17:5549690-5592266 (-)
PWK/PhJ	MGP_PWKPhJ_G0022121	protein coding gene	Chr17:4892939-4939991 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021950	protein coding gene	Chr17:4819538-4855867 (-)
WSB/EiJ	MGP_WSBEiJ_G0022429	protein coding gene	Chr17:5632193-5672674 (-)

Human Ortholog

RNASET2, ribonuclease T2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNASET2, ribonuclease T2
Synonyms

bA514O12.3, RNASE6PL
Links

HGNC:21686

NCBI Gene ID: 8635

neXtProt AC: NX_O00584

UniProt: O00584
Chr Location

6q27; chr6:166922113-166957191 (-) GRCh38

MGI Vertebrate Homology

Rnaset2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNASET2
Gene Tree

Rnaset2b

Diseases

7 with human RNASET2 associations

				Human Disease	Mouse Models
				colon adenocarcinoma IDs colon adenocarcinoma DOID:234 MESH:D003110 NCI:C4349 UMLS_CUI:C0338106
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				Lynch syndrome IDs Lynch syndrome DOID:3883 DOID:0050586 DOID:3040 MESH:D003123 NCI:C8494 OMIM:PS120435 ORDO:144 UMLS_CUI:C0009405 UMLS_CUI:C4552100
				melanoma IDs melanoma DOID:1909 EFO:0000756 KEGG:05218 MESH:D008545 NCI:C3224 UMLS_CUI:C0025202
				mismatch repair cancer syndrome IDs mismatch repair cancer syndrome DOID:0112182 OMIM:276300 ORDO:252202
				RNASET2-deficient cystic leukoencephalopathy IDs RNASET2-deficient cystic leukoencephalopathy DOID:0081007 OMIM:612951 ORDO:85136

Click on a disease name to see all genes associated with that disease.

References

6 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
359 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Radiation induced

8
Targeted

2
Genomic Mutations

8 involving Rnaset2b
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

933
Tissues

149
cDNA Data

65
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

2
UniProt

1
CCDS

CCDS37429.1

Ensembl

ENSMUSG00000094724 (Evidence)
NCBI Gene

68195

			Length	Strain/Species	Flank
genomic	68195	NCBI Gene Model \| MGI Sequence Detail	19334	C57BL/6J	± kb
transcript	NM_026611	RefSeq \| MGI Sequence Detail	1031	C57BL/6
polypeptide	C0HKG6	UniProt \| EBI \| MGI Sequence Detail	259	Not Applicable

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UniProt

1 Sequence
GlyGen

C0HKG6 3 sites

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All nucleic 69

cDNA 68

Primer pair 1

Summaries

All 385

Developmental Gene Expression 5

Diseases 6

Gene Ontology 7

Phenotypes 359
Earliest

J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
Latest

J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24