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Dux Complex/Cluster/Region Detail
Summary
  • Symbol
    Dux
  • Name
    double homeobox
  • Synonyms
    D4Z4, Duxbl, EG664783
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:3703875
    NCBI Gene: 664783
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 10, Syntenic
  • Mapping Data
    3 experiments
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deletion of the macrosatellite repeat region results in pre- and post-implantation developmental defects, alterations in the first few embryonic cell divisions, and perinatal lethality in a subset of embryos derived from homozygous crosses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    33
  • Tissues
    17
  • Literature Summary
    7
  • Other Mouse Links
    GEO
Sequences &
Gene Models
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  • All Sequences
    8
  • RefSeq
    2
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic AM398149 GenBank | ENA | DDBJ | MGI Sequence Detail 4899 C57BL/6 ±  kb
transcript NM_001081954 RefSeq | MGI Sequence Detail 2025 ZRU/MplStud  
polypeptide NP_001075423 RefSeq | MGI Sequence Detail 674 ZRU/MplStud  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001356 Homeobox domain
    IPR051306 Homeobox domain-containing regulator
    IPR009057 Homeobox-like domain superfamily
Molecular
Reagents
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  • All nucleic 13
    cDNA 1
    Primer pair 12

    Microarray probesets 2
Other
Accession IDs
less
MGI:3704116
References
more
  • Summaries
    All 32
    Developmental Gene Expression 7
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:126165 Clapp J, et al., Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. Am J Hum Genet. 2007 Aug;81(2):264-79
  • Latest
    J:346215 Vega-Sendino M, et al., The homeobox transcription factor DUXBL controls exit from totipotency. Nat Genet. 2024 Mar 20;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory