Tg(Pbsn-Tag)12T7fRjm
Transgene Detail

Summary

• Symbol: Tg(Pbsn-Tag)12T7fRjm
• Name: transgene insertion 12T7f, Robert J Matusik
• MGI ID: MGI:3706555
• Synonyms: LADY 12T-7f, LBP-Tag
• Transgene: Tg(Pbsn-Tag)12T7fRjm Location: unknown
• Alliance: Tg(Pbsn-Tag)12T7fRjm page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene includes the SV40 large T antigen (Tag) gene, containing a deletion in the early region that eliminates expression of small T antigen, driven by the rat probasin promoter fragment extending from -11500 to +28 bp ("large probasin promoter"). Seven lines were established: 12T-1, 12T-5, 12T-7f, 12T-7s, 12T-8. 12T-10, and 12T-11. This 12T-7f line contains multiple copies of the transgene. (J:48623)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pbsn-Tag)12T7fRjm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic lines were established and maintained in the CD1 mouse strain.

References

• Original: J:48623 Kasper S, et al., Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer [corrected and republished article originally printed in Lab Invest 1998 Mar;78(3):319-33]. Lab Invest. 1998 Jun;78(6):i-xv
• All: 14 reference(s)