Tg(HLA-A/H2-D/B2M)1Dvs
Transgene Detail

Summary

• Symbol: Tg(HLA-A/H2-D/B2M)1Dvs
• Name: transgene insertion 1, David Serreze
• MGI ID: MGI:3711057
• Synonyms: HDD, HHD
• Transgene: Tg(HLA-A/H2-D/B2M)1Dvs Location: unknown
• Alliance: Tg(HLA-A/H2-D/B2M)1Dvs page

Transgene origin

• Strain of Origin: NOD/ShiLtDvs

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(HLA-A/H2-D/B2M)1Dvs expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  B2M (567)

  B2m	(MGI:88127)

• Mutation details: This transgene encodes a human B2-microglubulin (B2M) covalently linked to the MHC class 1, alpha1 and alpha2 binding domains of the human HLA-A2.1 gene, and the alpha3, cytoplasmic and transmembrane domains of the murine H2-D^b. The construct was injected into fertilized NOD/ShiLtDvs oocytes. The construct was originally described in J:41077 and used to create a different transgenic line. (J:41077, J:121685)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available

Notes

The HDD construct was created and used to generate a differnet transgenic mouse line in J:41077.

References

• Original: J:121685 Takaki T, et al., HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol. 2006 Mar 1;176(5):3257-65
• All: 23 reference(s)