Amy2a4 Gene Detail

Summary

• Symbol
  Amy2a4
• Name
  amylase 2a4
• Synonyms
  mAmy2-3

• Feature Type
  protein coding gene
• IDs
  MGI:3711258
  NCBI Gene: 100043684
• Member of
  Amy cluster
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr3:113187159-113198765 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 49.35 cM
• Mapping Data
  1 experiment

Strain
Comparison

• Strain Annotations
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3711258	protein coding gene	Chr3:113187153-113198765 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0027723	protein coding gene	Chr3:116547642-116575237 (-)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Human Ortholog
  AMY1A, amylase alpha 1A

• Vertebrate Orthologs
  7

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  AMY1A, amylase alpha 1A
  
• Synonyms
  AMY1
• Links
  HGNC:474

  NCBI Gene ID: 276

  neXtProt AC: NX_P0DTE7, NX_P0DTE8, NX_P0DUB6

  UniProt: P0DUB6

  
  
• Chr Location
  1p21.1; chr1:103655519-103664554 (+)  GRCh38

---

• Human Ortholog
  AMY1B, amylase alpha 1B
  
• Synonyms
  AMY1
• Links
  HGNC:475

  NCBI Gene ID: 277

  neXtProt AC: NX_P0DTE7, NX_P0DTE8, NX_P0DUB6

  UniProt: P0DTE7

  
  
• Chr Location
  1p21.1; chr1:103687415-103696454 (-)  GRCh38

---

• Human Ortholog
  AMY1C, amylase alpha 1C
  
• Synonyms
  AMY1
• Links
  HGNC:476

  NCBI Gene ID: 278

  neXtProt AC: NX_P0DTE7, NX_P0DTE8, NX_P0DUB6

  UniProt: P0DTE8

  
  
• Chr Location
  1p21.1; chr1:103745323-103758726 (+)  GRCh38

---

• Human Ortholog
  AMY2A, amylase alpha 2A
  
• Synonyms
  AMY2, PA
• Links
  HGNC:477

  NCBI Gene ID: 279

  neXtProt AC: NX_P04746

  UniProt: P04746

  
  
• Chr Location
  1p21.1; chr1:103616651-103625780 (+)  GRCh38

---

• Human Ortholog
  AMY2B, amylase alpha 2B
  
• Synonyms
  AMY2, AMY3, HXA
• Links
  HGNC:478

  NCBI Gene ID: 280

  neXtProt AC: NX_P19961

  UniProt: P19961

  
  
• Chr Location
  1p21.1; chr1:103553815-103579534 (+)  GRCh38

---

• MGI Vertebrate Homology
  Amy2a4 stringent orthology
  5 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: AMY1A, AMY1B, AMY1C, AMY2A, AMY2B
• Gene Tree
  Amy2a4
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotype references
  

• All Mutations and Alleles
  2
• Chemically induced (other)
  1
• Radiation induced
  1
• Genomic Mutations
  2 involving Amy2a4
• Find Mice (IMSR)
  0 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  17
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  2

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  12
• RefSeq
  2
• CCDS
  CCDS51054.1

• Ensembl
  ENSMUSG00000096770 (Evidence)
• NCBI Gene
  100043684

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000096770	Ensembl Gene Model | MGI Sequence Detail	11607	C57BL/6J
transcript	ENSMUST00000179568	Ensembl | MGI Sequence Detail	3717	Not Applicable
polypeptide	ENSMUSP00000137025	Ensembl | MGI Sequence Detail	508	Not Applicable

Molecular
Reagents

• All nucleic 3

  cDNA 3

References

• Summaries
  All 21

  Diseases 1

  Gene Ontology 2

  Phenotypes 4
• Earliest
  J:6365 Hagenbuchle O, et al., Tissue-specific expression of mouse-alpha-amylase genes: nucleotide sequence of isoenzyme mRNAs from pancreas and salivary gland. Cell. 1980 Aug;21(1):179-87
• Latest
  J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426