Tg(Ighm-Ctla4Ig/Cd80)1Jbs
Transgene Detail

Summary

• Symbol: Tg(Ighm-Ctla4Ig/Cd80)1Jbs
• Name: transgene insertion 1, Jeffery Bluestone
• MGI ID: MGI:3711772
• Synonyms: ScalphaCtla-4, Tg(Ighm-Igh/Igk/Cd80)1Jbs, Tg ScalphaCtla-4, u.7M-4F10scFv-B7.1
• Transgene: Tg(Ighm-Ctla4Ig/Cd80)1Jbs Location: unknown
• Alliance: Tg(Ighm-Ctla4Ig/Cd80)1Jbs page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains a mouse anti-Ctla4Ig/Cd80 fusion cDNA from which a cell surface bound form of the CD152 antigen (Ctla4Ig) is expressed under control of the IgM heavy chain promoter and enhancer, which directs expression to B cells. To prevent reverse signaling in the transgene expressing cell, the construct was created using a DNA fragment expressing the transmembrane domain from Cd80(B7-1), which lacks the C-terminal, intra-cytoplasmic tail. (J:113109)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:113109 Fife BT, et al., Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest. 2006 Aug;116(8):2252-61
• All: 1 reference(s)