Krtap6-3 Gene Detail

Summary

• Symbol
  Krtap6-3
• Name
  keratin associated protein 6-3
• Synonyms
  Gm10229

• Feature Type
  protein coding gene
• IDs
  MGI:3711943
  NCBI Gene: 100040201
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr16:88812172-88812734 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 16, 51.42 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  167 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3711943	protein coding gene	Chr16:88812165-88812734 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023006	protein coding gene	Chr16:89831756-89832325 (+)
A/J	MGP_AJ_G0022974	protein coding gene	Chr16:85673794-85674363 (+)
AKR/J	MGP_AKRJ_G0022944	protein coding gene	Chr16:88280340-88280909 (+)
BALB/cJ	MGP_BALBcJ_G0022976	protein coding gene	Chr16:86207070-86207840 (+)
C3H/HeJ	MGP_C3HHeJ_G0022737	protein coding gene	Chr16:88843671-88844240 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023423	protein coding gene	Chr16:92730318-92730993 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020927	protein coding gene	Chr16:83478026-83478572 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0022706	protein coding gene	Chr16:96688292-96688861 (+)
DBA/2J	MGP_DBA2J_G0022840	protein coding gene	Chr16:85606204-85606773 (+)
FVB/NJ	MGP_FVBNJ_G0022815	protein coding gene	Chr16:84700735-84701304 (+)
LP/J	MGP_LPJ_G0022910	protein coding gene	Chr16:89527250-89527819 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022835	protein coding gene	Chr16:101287904-101288504 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023441	protein coding gene	Chr16:88773109-88774414 (+)
PWK/PhJ	MGP_PWKPhJ_G0022003	protein coding gene	Chr16:85754572-85755241 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021833	protein coding gene	Chr16:88336746-88337292 (+)
WSB/EiJ	MGP_WSBEiJ_G0022308	protein coding gene	Chr16:89013793-89017561 (+)

Homology

• Human Ortholog
  KRTAP6-3, keratin associated protein 6-3

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  KRTAP6-3, keratin associated protein 6-3
  
• Synonyms
  KAP6.3
• Links
  HGNC:18933

  NCBI Gene ID: 337968

  UniProt: Q3LI67

  
  
• Chr Location
  21q22.11; chr21:30592440-30593075 (+)  GRCh38

---

• MGI Vertebrate Homology
  Krtap6-3 stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: KRTAP6-3
• Gene Tree
  Krtap6-3
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  3
• Targeted
  2
• Genomic Mutations
  3 involving Krtap6-3
• Find Mice (IMSR)
  1 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706
• cDNA Data
  3

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  27
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS49897.1

• Ensembl
  ENSMUSG00000068075 (Evidence)
• NCBI Gene
  100040201

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000068075	Ensembl Gene Model | MGI Sequence Detail	563	C57BL/6J
transcript	ENSMUST00000089106	Ensembl | MGI Sequence Detail	563	Not Applicable
polypeptide	ENSMUSP00000086507	Ensembl | MGI Sequence Detail	77	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR040313 Keratin-associated protein 6

Molecular
Reagents

• All nucleic 6

  cDNA 6

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:7539723

References

• Summaries
  All 20

  Phenotypes 6
• Earliest
  J:44334 Aoki N, et al., Isolation and characterization of mouse high-glycine/tyrosine proteins. J Biol Chem. 1997 Nov 28;272(48):30512-8
• Latest
  J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077