About   Help   FAQ
Pnp2 Gene Detail
Summary
  • Symbol
    Pnp2
  • Name
    purine-nucleoside phosphorylase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3712328
    NCBI Gene: 667034
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51193598-51202206 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3712328
 protein coding gene Chr14:51193449-51202206 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0021659
 protein coding gene Chr14:46743976-46745616 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0020528
 protein coding gene Chr14:42092512-42100869 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PNP, purine nucleoside phosphorylase
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PNP, purine nucleoside phosphorylase
  • Synonyms
    NP, PRO1837, PUNP
  • Links
    NCBI Gene ID: 4860
    neXtProt AC: NX_P00491
    UniProt: P00491

  • Chr Location
    14q11.2; chr14:20461992-20477094 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PNP associations

Human Disease Mouse Models
      
IDs
 View 5 models
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    2
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 667034 NCBI Gene Model | MGI Sequence Detail 8609 C57BL/6J ±  kb
transcript NM_001123371 RefSeq | MGI Sequence Detail 1223 C57BL/6  
polypeptide NP_001116843 RefSeq | MGI Sequence Detail 305 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    2.4.2.1
  • InterPro Domains
    IPR000845 Nucleoside phosphorylase domain
    IPR035994 Nucleoside phosphorylase superfamily
    IPR011268 Purine nucleoside phosphorylase
    IPR011270 Purine nucleoside phosphorylase I, inosine/guanosine-specific
    IPR018099 Purine phosphorylase, family 2, conserved site
Molecular
Reagents
less
  • All nucleic 3
    cDNA 2
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
  • Latest
    J:339075 Fan KQ, et al., Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior. Cell. 2019 Oct 31;179(4):864-879.e19
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory