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Pramel15 Gene Detail
Summary
  • Symbol
    Pramel15
  • Name
    PRAME like 15
  • Synonyms
    EG627009, Gm13125, Pramef20
  • Feature Type
    protein coding gene
  • IDs
    MGI:3712553
    NCBI Gene: 627009
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:144099330-144104503 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 77.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3712553
 protein coding gene Chr4:144099330-144104530 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029089
 protein coding gene Chr4:147730848-147737035 (-)
A/J MGP_AJ_G0029056
 protein coding gene Chr4:141455740-141461443 (-)
AKR/J MGP_AKRJ_G0029004
 protein coding gene Chr4:145434043-145441611 (-)
BALB/cJ MGP_BALBcJ_G0029071
 protein coding gene Chr4:142103341-142114560 (-)
C3H/HeJ MGP_C3HHeJ_G0028790
 protein coding gene Chr4:145873246-145887893 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029516
 protein coding gene Chr4:152733007-152739600 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0028206
 protein coding gene Chr4:143950604-143961395 (-)
CBA/J MGP_CBAJ_G0028754
 protein coding gene Chr4:157481038-157498546 (-)
DBA/2J MGP_DBA2J_G0028902
 protein coding gene Chr4:141681239-141689936 (-)
FVB/NJ MGP_FVBNJ_G0028864
 protein coding gene Chr4:140817736-140823278 (-)
LP/J MGP_LPJ_G0028993
 protein coding gene Chr4:147789485-147796975 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028894
 protein coding gene Chr4:161068182-161077572 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029553
 protein coding gene Chr4:145897739-145902776 (-)
PWK/PhJ MGP_PWKPhJ_G0027926
 protein coding gene Chr4:138158906-138163243 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027760
 protein coding gene Chr4:141171981-141178595 (-)
WSB/EiJ MGP_WSBEiJ_G0028285
 protein coding gene Chr4:146162493-146169126 (-)



Homology
more
  • Human Ortholog
    PRAMEF13, PRAME family member 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRAMEF13, PRAME family member 13
  • Links
    NCBI Gene ID: 400736
    neXtProt AC: NX_Q5VWM6
    UniProt: Q5VWM6

  • Chr Location
    1p36.21; chr1:13196188-13201409 (-)  GRCh38
  • Human Ortholog
    PRAMEF20, PRAME family member 20
  • Synonyms
    PRAMEF21
  • Links
    NCBI Gene ID: 645425
    neXtProt AC: NX_Q5VT98
    UniProt: Q5VT98

  • Chr Location
    1p36.21; chr1:13410450-13421328 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRAME associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 627009 NCBI Gene Model | MGI Sequence Detail 5174 C57BL/6J ±  kb
transcript NM_001115077 RefSeq | MGI Sequence Detail 1434 C57BL/6  
polypeptide NP_001108549 RefSeq | MGI Sequence Detail 477 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR032675 Leucine-rich repeat domain superfamily
    IPR026271 PRAME
    IPR050694 PRAME domain-containing protein
Molecular
Reagents
less

  • Microarray probesets 1
Other
Accession IDs
less
MGI:3643657, MGI:5896362, MGI:6430512
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 10
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:354132 Tan J, et al., Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation. Nat Commun. 2024 Aug 25;15(1):7310
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory