Srp54c MGI Mouse Gene Detail - MGI:3714359 - signal recognition particle 54C

Symbol

Srp54c
Name

signal recognition particle 54C
Synonyms

E330029E12Rik

Feature Type

protein coding gene
IDs

MGI:3714359
NCBI Gene: 100101806
Alliance

gene page

Sequence Map

Chr12:55276953-55310621 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 23.89 cM
Mapping Data

3 experiments

SNPs within 2kb

272 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3714359	protein coding gene	Chr12:55276896-55326120 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019744	protein coding gene	Chr12:54049837-54076685 (+)
A/J	no annotation
AKR/J	MGP_AKRJ_G0019676	protein coding gene	Chr12:53929851-53973485 (+)
BALB/cJ	MGP_BALBcJ_G0019683	protein coding gene	Chr12:52430344-52468886 (+)
C3H/HeJ	MGP_C3HHeJ_G0019486	protein coding gene	Chr12:53827080-53862286 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020135	protein coding gene	Chr12:55868831-55906007 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017754	protein coding gene	Chr12:50404743-50439276 (+)
CAST/EiJ	MGP_CASTEiJ_G0019039	protein coding gene	Chr12:48860082-48894903 (+)
CBA/J	MGP_CBAJ_G0019458	protein coding gene	Chr12:57815431-57862238 (+)
DBA/2J	MGP_DBA2J_G0019572	protein coding gene	Chr12:51988045-52030562 (+)
FVB/NJ	MGP_FVBNJ_G0019561	protein coding gene	Chr12:51463929-51494138 (+)
LP/J	MGP_LPJ_G0019644	protein coding gene	Chr12:54103147-54145861 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019597	protein coding gene	Chr12:59226922-59371862 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020169	protein coding gene	Chr12:53205382-53239706 (+)
PWK/PhJ	MGP_PWKPhJ_G0018806	protein coding gene	Chr12:46564954-46599499 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018600	protein coding gene	Chr12:47787989-47807633 (+)
WSB/EiJ	MGP_WSBEiJ_G0019090	protein coding gene	Chr12:53866185-53915948 (+)

Human Ortholog

SRP54, signal recognition particle 54

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRP54, signal recognition particle 54
Synonyms

SCN8
Links

HGNC:11301

NCBI Gene ID: 6729

neXtProt AC: NX_P61011

UniProt: P61011
Chr Location

14q13.2; chr14:34981957-35029686 (+) GRCh38

MGI Vertebrate Homology

Srp54c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRP54
Gene Tree

Srp54c

Diseases

1 with human SRP54 associations

				Human Disease	Mouse Models
				severe congenital neutropenia 8 IDs severe congenital neutropenia 8 DOID:0112135 OMIM:618752

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Gene trapped

1
Genomic Mutations

1 involving Srp54c
Find Mice (IMSR)

5 strains or lines available

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All GO Annotations

17
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

45
RefSeq

8
UniProt

3
CCDS

CCDS49067.1

Ensembl

ENSMUSG00000079108 (Evidence)
NCBI Gene

100101806

			Length	Strain/Species	Flank
genomic	ENSMUSG00000079108	Ensembl Gene Model \| MGI Sequence Detail	33669	C57BL/6J	± kb
transcript	ENSMUST00000218879	Ensembl \| MGI Sequence Detail	3642	Not Applicable
polypeptide	ENSMUSP00000151681	Ensembl \| MGI Sequence Detail	504	Not Applicable

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UniProt

3 Sequences
EC

3.6.5.-
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR028260 FAM177 family

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR013822 Signal recognition particle SRP54, helical bundle

IPR042101 Signal recognition particle SRP54, N-terminal domain superfamily

IPR022941 Signal recognition particle, SRP54 subunit

IPR006325 Signal recognition particle, SRP54 subunit, eukaryotic

IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain

IPR004125 Signal recognition particle, SRP54 subunit, M-domain

IPR036891 Signal recognition particle, SRP54 subunit, M-domain superfamily

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All nucleic 11

cDNA 11

Microarray probesets 3

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MGI:2442031

Summaries

All 22

Gene Ontology 2

Phenotypes 3
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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