Tg(Thy1-APPLon)2Vln
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPLon)2Vln
• Name: transgene insertion 2, Fred Van Leuven
• MGI ID: MGI:3717572
• Synonyms: APP/Ld/2, APP/V717I, Tg(Thy1-APP*Lon)2Vln, Tg(Thy1-APP*V642I)2Vln
• Transgene: Tg(Thy1-APPLon)2Vln Location: unknown
• Alliance: Tg(Thy1-APPLon)2Vln page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPLon)2Vln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the London mutation.

• Mutation details: cDNA encoding the human London (V642I) amyloid precursor protein variant (695 isoform) was cloned into the pTSC vector in the mouse Thy1 gene. The linearized minigene was injected into prenuclear embryos from FVB/N females. Human mutant APP protein is expressed in hippocampus, parietal and frontal cortices at 2-5 times the endogenous APP levels, at lower levels in olfactory bulb and thalamus, and at very low levels in the cerebellum. (J:53800)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:53800 Moechars D, et al., Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem. 1999 Mar 5;274(10):6483-92
• All: 32 reference(s)