Tg(Thy1-MAPT)1Vln
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT)1Vln
• Name: transgene insertion 1, Fred Van Leuven
• MGI ID: MGI:3720113
• Synonyms: htau40-1, tau-4R/2N, thy-1.1-tau
• Transgene: Tg(Thy1-MAPT)1Vln Location: unknown
• Alliance: Tg(Thy1-MAPT)1Vln page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT)1Vln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: Human MAPT cDNA encoding the longest tau isoform of 441 amino acids (called tau40) containing four repeats, with 2 N-terminal inserts was inserted into a murine Thy1 expression vector. Founder line 1 was established by breeding with FVB/N females. Expression of human tau (MAPT) protein exclusively in brain and spinal cord was detected by Western blotting. (J:100972)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
cx1  Disease Model	Tg(GSK3B*S9A)1Vln/0 Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln	involves: FVB
tg2  Disease Model	Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln	involves: FVB
tg3	Tg(Thy1-MAPT)1Vln/0	FVB/N-Tg(Thy1-MAPT)1Vln
tg4	Tg(Thy1-MAPT)1Vln/0	involves: FVB

Phenotypes:

Affected Systems	cx1	tg2	tg3	tg4
show or hide all annotated terms
behavior/neurological	√	√	√	√
behavior/neurological phenotype	N
abnormal postural reflex		√
impaired righting response		√
limb grasping		√	√
abnormal motor coordination/balance			√
impaired coordination	√	√		√
abnormal locomotor activation		√		√
cellular		√
abnormal cell cytoskeleton morphology		√
growth/size/body		√
decreased body weight		√
muscle	N	√	√
muscle phenotype	N
decreased skeletal muscle mass		√
muscular atrophy		√	√
skeletal muscle fiber atrophy		√
muscle weakness		√
nervous system	√	√	√	√
nervous system phenotype		N
tau protein deposits		√
astrocytosis		√
abnormal neuron morphology		√
abnormal axon morphology	√	√	√	√
axon degeneration		√	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cx1	tg2
Alzheimer's disease IDs Alzheimer's disease       DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395 Close	√	√

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100972 Spittaels K, et al., Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. Am J Pathol. 1999 Dec;155(6):2153-65
• All: 7 reference(s)