Tg(Thy1-APPSwDutIowa)BWevn
Transgene Detail
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Symbol: |
Tg(Thy1-APPSwDutIowa)BWevn |
Name: |
transgene insertion B, William E Van Nostrand |
MGI ID: |
MGI:3721992 |
Synonyms: |
APPSwDI, Tg-SwDI, Tg-SwDI/B |
Transgene: |
Tg(Thy1-APPSwDutIowa)BWevn Location: unknown
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Alliance: |
Tg(Thy1-APPSwDutIowa)BWevn page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Thy1-APPSwDutIowa)BWevn expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APP (351) |
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Mutation details: A transgenic construct containing 2.1kb of the human amyloid beta-precursor protein, APP gene, 770 isoform, with the Swedish K670N/M671L, Dutch E693Q and Iowa D694N mutations, under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter was injected into fertilized C57BL/6 mouse eggs. Founder line B was subsequently established and homozygotes generated. Human amyloid beta precursor protein expression is detected in the brains of transgenic mice. Two other lines, A anc C were also generated, with line A having similar levels of transgene expression and amyloid beta accumulation to line B while line C has 2-fold higher expression of human Amyloid beta-precursor protein and shows 4-fold higher accumulations of soluble and insoluble AB peptides in the brain.
(J:89848)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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Original: |
J:89848 Davis J, et al., Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem. 2004 May 7;279(19):20296-306 |
All: |
80 reference(s) |
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