Tg(CMV-Msx2*P7H)1Rem
Transgene Detail

Summary

• Symbol: Tg(CMV-Msx2*P7H)1Rem
• Name: transgene insertion 1, Robert E Maxson
• MGI ID: MGI:3762251
• Synonyms: CMV-Msx2-Pro7His
• Transgene: Tg(CMV-Msx2*P7H)1Rem Location: unknown
• Alliance: Tg(CMV-Msx2*P7H)1Rem page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-Msx2*P7H)1Rem expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Msx2 (MGI:97169)

• Mutation details: This transgene consists of a 1.1-kb fragment of the mouse Msx2 gene containing 0.3 kb of the 3.5-kb intron and a PCR-mutagenized version of the second exon bearing the Pro7His mutation under the control of human cytomegalovirus (CMV) promoter. This single base pair mutation is seen in individuals affected with Boston-type craniosynostosis. (J:26513)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:26513 Liu YH, et al., Premature suture closure and ectopic cranial bone in mice expressing Msx2 transgenes in the developing skull. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6137-41
• All: 1 reference(s)