Tg(Th-SNCA*)1.2Ccs
Transgene Detail

Summary

• Symbol: Tg(Th-SNCA*)1.2Ccs
• Name: transgene insertion 1.2, Christine C Stichel
• MGI ID: MGI:3764815
• Synonyms: msTH, THsyn
• Transgene: Tg(Th-SNCA*)1.2Ccs Location: unknown
• Alliance: Tg(Th-SNCA*)1.2Ccs page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Th-SNCA*)1.2Ccs expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Tg(Th-SNCA*)1.2Ccs expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Th (MGI:98735)

• Mutation details: This transgene contains a double mutant human SNCA with amino acid substitutions of proline for alanine at position 30 (A30P) and threonine for alanine at position 53 (A53T) under the control of a mouse tyrosine hydroxylase promoter. Expression is detected in the brain. (J:127708)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Two lines were created with similar expression patterns and line 1.2 was choosen as the representative line.

References

• Original: J:127708 Maskri L, et al., Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice. Neurodegener Dis. 2004;1(6):255-65
• All: 4 reference(s)