Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
• Name: transgene insertion 21, Mathias Jucker
• MGI ID: MGI:3765351
• Synonyms: APP.PS1, APPPS1, APPPS1-21, Tg(Thy1-APP*Swe,Thy1-PSEN1*L166P)21Jckr
• Transgene: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Location: unknown
• Alliance: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Swedish mutations.

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

• Mutation details: The Thy1-APPKM670/671NL was constructed with the mutant human APPKM670/671NL cDNA (Swedish or KM670/671NL mutation of amyloid precursor protein (APP)) placed downstream of the murine Thy1.2 promoter region. Additionally, the Thy1-PS1L166P transgene was constructed with a mutant human PS1L166P cDNA (leucine to proline mutation at position 166 of human presenilin 1 (Alzheimer disease 3, PSEN1 or PS1)) placed downstream of the murine Thy1.2 promoter sequences. These constructs were coinjected to produce founder mice. In addition to line 21, lines 5 and 8 were also established. (J:116895)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:116895 Radde R, et al., Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep. 2006 Sep;7(9):940-6
• All: 154 reference(s)