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Timo Other Genome Feature Detail
Summary
  • Symbol
    Timo
  • Name
    transgenic insertional mutants with obesity
  • Feature Type
    unclassified other genome feature
  • IDs
    MGI:3766098
Location &
Maps
less
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 2, Syntenic
Human Diseases
more
  • Diseases
    2 with Timo mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice display severe obesity, polyphagia, increased fat and lean mass, increased aggression to other mice, elevated leptin, insulin, cholesterol, and glucose levels, insulin resistance, and impaired glucose tolerance. Hemizygous mice show obesity and elevated LDL cholesterol.
References
more
  • Summaries
    All 3
    Diseases 1
    Phenotypes 2
  • Earliest
    J:127183 Sha H, et al., Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice. Physiol Genomics. 2007 Oct 22;31(2):252-63
  • Latest
    J:234396 Jiang S, et al., Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice. Am J Pathol. 2016 Aug;186(8):2117-28
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory