Tg(TcraR28,TcrbR28)KRNDim
Transgene Detail
|
|
| Symbol: |
Tg(TcraR28,TcrbR28)KRNDim |
| Name: |
transgene insertion KRN, Diane Mathis |
| MGI ID: |
MGI:3767242 |
| Synonyms: |
K/B, KRN, KRN-TCR |
| Transgene: |
Tg(TcraR28,TcrbR28)KRNDim Location: unknown
|
| Alliance: |
Tg(TcraR28,TcrbR28)KRNDim page
|
|
| Strain of Origin: |
(C57BL/6 x SJL)F2
|
|
| Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
| Mutation: |
|
Insertion
|
| |
|
Tg(TcraR28,TcrbR28)KRNDim expresses
2 genes
|
| |
|
Mutation details: The sequences of the variable regions of the TCR alpha and beta chains of the R28 hybridoma with rearranged Va4Ja27 and Vb6Jb1.5 genomic DNA fragments were amplified and cloned into TCR expression cassettes. Transgene-derived clones are transcribed under the control of the natural TCR alpha and -beta promoter/enhancer elements. A single founder (KRN) in which TCRalpha and Tcrbeta transgenes were cointegrated was identified. These constructs together express a T cell receptor that recognizes the 41-61 peptide of bovine pancreas ribonuclease (RNase) in the context of Ak.
(J:36815)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:36815 Kouskoff V, et al., Organ-specific disease provoked by systemic autoimmunity. Cell. 1996 Nov 29;87(5):811-22 |
| All: |
110 reference(s) |
|
Analysis Tools
