Tg(tetO-DTA)1Gfi
Transgene Detail

Summary

• Symbol: Tg(tetO-DTA)1Gfi
• Name: transgene insertion 1, Glenn I Fishman
• MGI ID: MGI:3767624
• Synonyms: tet-DTA, tetO-DTA, tetO^DTA/+
• Transgene: Tg(tetO-DTA)1Gfi Location: unknown
• Alliance: Tg(tetO-DTA)1Gfi page

Cardiac fibrosis and ventricle dilatation in Tg(Myh6-tTA)6Smbf/0 Tg(tetO-DTA)1Gfi/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A transgenic construct was created, containing diphtheria toxin A sequence (DTA) under the control of heptamerized tetracycline operator, tetO sequences fused to a cytomegalovirus minimal promoter. (J:128617)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Narcolepsy J:211045, J:211046

References

• Original: J:128617 Lee P, et al., Conditional lineage ablation to model human diseases. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11371-6
• All: 43 reference(s)