Tg(CAG-AR*97Q)7-8Sobue
Transgene Detail

Summary

• Symbol: Tg(CAG-AR*97Q)7-8Sobue
• Name: transgene insertion 7-8, Gen Sobue
• MGI ID: MGI:3767716
• Synonyms: AR-97Q, Tg(ACTB-AR*97Q)7-8Sobu
• Transgene: Tg(CAG-AR*97Q)7-8Sobue Location: unknown
• Alliance: Tg(CAG-AR*97Q)7-8Sobue page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-AR*97Q)7-8Sobue expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AR (367)

  Ar	(MGI:88064)

• Mutation details: The chicken actin promoter with a CMV enhancer (CAGGS) was used to drive the expression of a human androgen receptor open reading frame that contained a block of 97 CAG repeats. (J:128619)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Five lines were created (2-6, 4-6, 7-8, 3-7, 8-5) with copy numbers of the transgene ranging from 1 to 3 in lines 2-6, 4-6 and 7-8. Lines are phenotypically identical and line 7-8 was selected as the representative line as it was used in a subsequent publication by the same author.

References

• Original: J:128619 Katsuno M, et al., Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron. 2002 Aug 29;35(5):843-54
• All: 18 reference(s)