Tg(Thy1-MAPT*P301L)2Vln
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT*P301L)2Vln
• Name: transgene insertion 2, Fred Van Leuven
• MGI ID: MGI:3768525
• Synonyms: tau-4R/2N-P301L, Tau.P301L
• Transgene: Tg(Thy1-MAPT*P301L)2Vln Location: unknown
• Alliance: Tg(Thy1-MAPT*P301L)2Vln page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT*P301L)2Vln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: A human MAPT cDNA encoding the longest tau isoform of 441 amino acids containing four repeats, with 2 N-terminal inserts, and also carrying an engineered mutation to alter codon 301 from one encoding proline to encoding leucine, was inserted into a murine Thy1 expression vector. Expression of the mutant human tau (MAPT*P301L) protein was detected in layers II, V and VI of the neocortex, in layer III of the entorhinal cortex, in thd basolateral amygdala, hippocampus, zona incerta of the thalamus, brain stem nuclei and spinal cord. (J:96869)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:96869 Terwel D, et al., Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. J Biol Chem. 2005 Feb 4;280(5):3963-73
• All: 19 reference(s)