Tg(Igh-Lmp2a)13FRdni
Transgene Detail

Summary

• Symbol: Tg(Igh-Lmp2a)13FRdni
• Name: transgene insertion 13F, R D Nicholls
• MGI ID: MGI:3769767
• Synonyms: EmuLMP2A, Tg^PWS/AS(del)
• Transgene: Tg(Igh-Lmp2a)13FRdni Location: unknown
• Alliance: Tg(Igh-Lmp2a)13FRdni page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The Ig heavy chain promoter with Emu enhancer element was used to drive the expression of the Epstein-Barr virus latent membrane protein 2A. Expression was confirmed by RT-PCR of brain extracts. (J:56614)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

9 lines were created with the eight others exhibiting lymphocyte cell lineage defects. Line 13F results in a deletion in chromosome 7 from Mkrn3 to Herc2 (Mkrn3, Ndn, Snurf/Snrpn, Ube3a, and Herc2 are deleted).

References

• Original: J:56614 Gabriel JM, et al., A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and angelman syndromes. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9258-63
• All: 6 reference(s)