Tg(IGFBP2)1Miel
Transgene Detail

Summary

• Symbol: Tg(IGFBP2)1Miel
• Name: transgene insertion 1, John Miell
• MGI ID: MGI:3769995
• Synonyms: line tg1
• Transgene: Tg(IGFBP2)1Miel Location: unknown
• Alliance: Tg(IGFBP2)1Miel page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(IGFBP2)1Miel expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGFBP2 (3485)

  Igfbp2

  (MGI:96437)

• Mutation details: The IGFBP-2 transgene (isolated from a human cosmid clone) contains the entire structural human IGFBP2 gene. This 39 kb transgene was microinjected into the pronucleus of FVB/N embryos. Two lines tg1 and tg2 were established and line tg1 was analyzed in detail. (J:121961)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:121961 Wheatcroft SB, et al., IGF-binding protein-2 protects against the development of obesity and insulin resistance. Diabetes. 2007 Feb;56(2):285-94
• All: 1 reference(s)