Tg(APOE-CYP3A4)A1Nki
Transgene Detail

Summary

• Symbol: Tg(APOE-CYP3A4)A1Nki
• Name: transgene insertion A1, The Netherlands Cancer Institute
• MGI ID: MGI:3775623
• Synonyms: Tg(APOE-CYP3A4)A1Ahs
• Transgene: Tg(APOE-CYP3A4)A1Nki Location: unknown
• Alliance: Tg(APOE-CYP3A4)A1Nki page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human APOE promoter through part of exon 2 were used to drive liver-specific expression of human CYP3A4. (J:132292)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:132292 van Herwaarden AE, et al., Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4. Drug Metab Dispos. 2005 Jul;33(7):892-5
• All: 6 reference(s)