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Mptx2 Gene Detail
Summary
  • Symbol
    Mptx2
  • Name
    mucosal pentraxin 2
  • Synonyms
    Gm11062
  • Feature Type
    protein coding gene
  • IDs
    MGI:3779286
    NCBI Gene: 100504232
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr1:173102028-173105323 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 80.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    269 from dbSNP Build 142
  • Strain Annotations
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3779286
 protein coding gene Chr1:173101949-173105344 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016806
 protein coding gene Chr1:179198067-179204884 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0017229
 protein coding gene Chr1:186430462-186432807 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0016148
 protein coding gene Chr1:176995645-176999702 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0017264
 protein coding gene Chr1:178097863-178100446 (+)
PWK/PhJ MGP_PWKPhJ_G0015935
 protein coding gene Chr1:170178459-170179173 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015717
 protein coding gene Chr1:175861673-175867027 (-)
WSB/EiJ MGP_WSBEiJ_G0016212
 protein coding gene Chr1:177067093-177070472 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Genomic Mutations
    2 involving Mptx2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    15 strains or lines available
Homozygous null mice exhibit aggravated MRSA infection-induced peritoneal injury, indicating increased susceptibility to MRSA infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 100504232 NCBI Gene Model | MGI Sequence Detail 3296 C57BL/6J ±  kb
transcript NM_001205011 RefSeq | MGI Sequence Detail 694 ZRU/MplStud  
polypeptide NP_001191940 RefSeq | MGI Sequence Detail 219 ZRU/MplStud  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    IPR051005 Pentraxin domain-containing protein
    IPR001759 Pentraxin-related
References
more
  • Summaries
    All 12
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:326562 Zhu J, et al., Mptx2 defends against peritoneal infection by methicillin-resistant staphylococcus aureus. Int Immunopharmacol. 2022 Jul;108:108856
  • Latest
    J:344311 Yan W, et al., Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol. 2024 Jan 13;7(1):94
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory