About   Help   FAQ
Ces1b Gene Detail
Summary
  • Symbol
    Ces1b
  • Name
    carboxylesterase 1B
  • Synonyms
    Gm5158
  • Feature Type
    protein coding gene
  • IDs
    MGI:3779470
    NCBI Gene: 382044
  • Member of
    Ces1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:93783356-93806645 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3779470
 protein coding gene Chr8:93783353-93806645 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033941
 protein coding gene Chr8:94381103-94420718 (-)
A/J MGP_AJ_G0033924
 protein coding gene Chr8:90664214-90688000 (-)
AKR/J MGP_AKRJ_G0033850
 protein coding gene Chr8:93209446-93232811 (-)
BALB/cJ MGP_BALBcJ_G0033916
 protein coding gene Chr8:90817936-90841334 (-)
C3H/HeJ MGP_C3HHeJ_G0033626
 protein coding gene Chr8:93925775-93949491 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034437
 protein coding gene Chr8:97851116-97876637 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031378
 protein coding gene Chr8:84582961-84610868 (-)
CAST/EiJ MGP_CASTEiJ_G0032958
 protein coding gene Chr8:93486542-93512879 (-)
CBA/J MGP_CBAJ_G0033602
 protein coding gene Chr8:101112009-101140900 (-)
DBA/2J MGP_DBA2J_G0033756
 protein coding gene Chr8:90203742-90243024 (-)
FVB/NJ MGP_FVBNJ_G0033703
 protein coding gene Chr8:89143403-89167059 (-)
LP/J MGP_LPJ_G0033848
 protein coding gene Chr8:94504770-94528882 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033745
 protein coding gene Chr8:103454239-103478255 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034455
 protein coding gene Chr8:93328427-93352407 (-)
PWK/PhJ MGP_PWKPhJ_G0032660
 protein coding gene Chr8:89554114-89577689 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032497
 protein coding gene Chr8:92180544-92211052 (-)
WSB/EiJ MGP_WSBEiJ_G0033070
 protein coding gene Chr8:93786249-93858326 (-)



Homology
more
  • Human Ortholog
    CES1, carboxylesterase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CES1, carboxylesterase 1
  • Synonyms
    ACAT, CE-1, CEH, CES2, hCE-1, HMSE, HMSE1, PCE-1, REH, SES1, TGH
  • Links
    NCBI Gene ID: 1066
    neXtProt AC: NX_P23141
    UniProt: P23141

  • Chr Location
    16q12.2; chr16:55802851-55833337 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CES1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078964 Ensembl Gene Model | MGI Sequence Detail 23290 C57BL/6J ±  kb
transcript ENSMUST00000109582 Ensembl | MGI Sequence Detail 1964 Not Applicable  
polypeptide ENSMUSP00000105210 Ensembl | MGI Sequence Detail 567 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    3.1.1.-
  • InterPro Domains
    IPR029058 Alpha/Beta hydrolase fold
    IPR002018 Carboxylesterase, type B
    IPR019826 Carboxylesterase type B, active site
    IPR019819 Carboxylesterase type B, conserved site
    IPR050309 Type-B Carboxylesterase/Lipase
  • GlyGen
    D3Z5G7 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 1
References
more
  • Summaries
    All 18
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:164863 Holmes RS, et al., Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome. 2010 Oct;21(9-10):427-41
  • Latest
    J:267654 Saul MC, et al., Genomic variants in an inbred mouse model predict mania-like behaviors. PLoS One. 2018;13(5):e0197624
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory