Krtap10-28 Gene Detail

Summary

• Symbol
  Krtap10-28
• Name
  keratin associated protein 10-28
• Synonyms
  Gm9508

• Feature Type
  protein coding gene
• IDs
  MGI:3779918
  NCBI Gene: 670895
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr10:77532375-77533067 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 39.72 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  76 from dbSNP Build 142
• Strain Annotations
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3779918	protein coding gene	Chr10:77532107-77533122 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Human Ortholog
  KRTAP10-10, keratin associated protein 10-10

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  KRTAP10-10, keratin associated protein 10-10
  
• Synonyms
  KAP10.10, KAP18.10, KRTAP18-10, KRTAP18.10
• Links
  HGNC:22972

  NCBI Gene ID: 353333

  neXtProt AC: NX_P60014

  UniProt: P60014

  
  
• Chr Location
  21q22.3; chr21:44637356-44638455 (+)  GRCh38

---

• Human Ortholog
  KRTAP10-3, keratin associated protein 10-3
  
• Synonyms
  KAP10.3, KAP18-3, KAP18.3, KRTAP10.3, KRTAP18-3, KRTAP18.3
• Links
  HGNC:22968

  NCBI Gene ID: 386682

  neXtProt AC: NX_P60369

  UniProt: P60369

  
  
• Chr Location
  21q22.3

---

• Human Ortholog
  KRTAP10-7, keratin associated protein 10-7
  
• Synonyms
  KAP10.7, KAP18.7, KRTAP18-7
• Links
  HGNC:22970

  NCBI Gene ID: 386675

  neXtProt AC: NX_P60409

  UniProt: P60409

  
  
• Chr Location
  21q22.3; chr21:44600597-44602174 (+)  GRCh38

---

• MGI Vertebrate Homology
  Krtap10-28 stringent orthology
  3 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: KRTAP10-10, KRTAP10-3, KRTAP10-7
• Gene Tree
  Krtap10-28
  

Human Diseases

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  29 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Targeted
  3
• Genomic Mutations
  4 involving Krtap10-28
• Find Mice (IMSR)
  4 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  8
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS88032.1

• Ensembl
  ENSMUSG00000112170 (Evidence)
• NCBI Gene
  670895

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000112170	Ensembl Gene Model | MGI Sequence Detail	693	C57BL/6J
transcript	ENSMUST00000220084	Ensembl | MGI Sequence Detail	693	Not Applicable
polypeptide	ENSMUSP00000151808	Ensembl | MGI Sequence Detail	230	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR002494 Keratin-associated protein

Other
Accession IDs

MGI:7580649

References

• Summaries
  All 37

  Diseases 2

  Gene Ontology 1

  Phenotypes 29
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:351211 Wu Y, et al., Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B. Acta Neuropathol Commun. 2023 Aug 14;11(1):132

TSS for Krtap10-28:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98241	Chr10:77533121-77533123 (-)	-55 bp