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Topaz1 Gene Detail
Summary
  • Symbol
    Topaz1
  • Name
    testis and ovary specific PAZ domain containing 1
  • Synonyms
    Gm9524
  • Feature Type
    protein coding gene
  • IDs
    MGI:3779933
    NCBI Gene: 671232
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:122576411-122631200 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 73.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1156 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3779933
 protein coding gene Chr9:122576264-122631200 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035461
 protein coding gene Chr9:125747405-125802834 (+)
A/J MGP_AJ_G0035442
 protein coding gene Chr9:120935197-120989869 (+)
AKR/J MGP_AKRJ_G0035375
 protein coding gene Chr9:124186730-124242830 (+)
BALB/cJ MGP_BALBcJ_G0035438
 protein coding gene Chr9:120856461-120911250 (+)
C3H/HeJ MGP_C3HHeJ_G0035145
 protein coding gene Chr9:124620588-124676677 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035961
 protein coding gene Chr9:129206881-129261538 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032843
 protein coding gene Chr9:118069097-118118112 (+)
CAST/EiJ MGP_CASTEiJ_G0034450
 protein coding gene Chr9:124648081-124703549 (+)
CBA/J MGP_CBAJ_G0035113
 protein coding gene Chr9:133925268-133985707 (+)
DBA/2J MGP_DBA2J_G0035272
 protein coding gene Chr9:120381197-120436674 (+)
FVB/NJ MGP_FVBNJ_G0035219
 protein coding gene Chr9:119303317-119357301 (+)
LP/J MGP_LPJ_G0035351
 protein coding gene Chr9:126088287-126143391 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035260
 protein coding gene Chr9:134792417-134847764 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035980
 protein coding gene Chr9:124642274-124697441 (+)
PWK/PhJ MGP_PWKPhJ_G0034154
 protein coding gene Chr9:120836094-120893657 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033991
 protein coding gene Chr9:124724623-124780857 (+)
WSB/EiJ MGP_WSBEiJ_G0034570
 protein coding gene Chr9:124486646-124541590 (+)



Homology
more
  • Human Ortholog
    TOPAZ1, testis and ovary specific TOPAZ 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOPAZ1, testis and ovary specific TOPAZ 1
  • Synonyms
    C3orf77
  • Links
    NCBI Gene ID: 375337
    neXtProt AC: NX_Q8N9V7
    UniProt: Q8N9V7

  • Chr Location
    3p21.31; chr3:44241886-44336689 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with abnormal meiosis and apoptosis of male germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    24
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000094985 Ensembl Gene Model | MGI Sequence Detail 54790 C57BL/6J ±  kb
    transcript ENSMUST00000178679 Ensembl | MGI Sequence Detail 5030 Not Applicable  
    polypeptide ENSMUSP00000136304 Ensembl | MGI Sequence Detail 1653 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 3
      Primer pair 2
    References
    more
    • Summaries
      All 15
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 2
    • Earliest
      J:181001 Baillet A, et al., TOPAZ1, a novel germ cell-specific expressed gene conserved during evolution across vertebrates. PLoS One. 2011;6(11):e26950
    • Latest
      J:328509 Chadourne M, et al., Structural and Functional Characterization of a Testicular Long Non-coding RNA (4930463O16Rik) Identified in the Meiotic Arrest of the Mouse Topaz1 (-/-) Testes. Front Cell Dev Biol. 2021;9:700290
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory