Tg(ACTA1-Ar)141Kyjo
Transgene Detail

Summary

• Symbol: Tg(ACTA1-Ar)141Kyjo
• Name: transgene insertion 141, Cynthia L Jordan
• MGI ID: MGI:3794206
• Synonyms: HSA-AR
• Transgene: Tg(ACTA1-Ar)141Kyjo Location: unknown
• Alliance: Tg(ACTA1-Ar)141Kyjo page

Transgene origin

• Strain of Origin: C4 x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-Ar)141Kyjo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Ar (24208)

  Ar	(MGI:88064)

• Mutation details: The human skeletal alpha-actin (HSA) promoter was used to drive expression of the rat Ar in skeletal muscles fibers. Seven lines were created with lines 78 (lower copy number) and 141 (higher copy number) characterized further for expression in skeletal muscle fibers. (J:127205)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127205 Monks DA, et al., Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18259-64
• All: 10 reference(s)