Tg(Myh6*)1Lnwd
Transgene Detail

Summary

• Symbol: Tg(Myh6*)1Lnwd
• Name: transgene insertion 1, Leslie Leinwand
• MGI ID: MGI:3793766
• Synonyms: deltaLCBDmyc
• Transgene: Tg(Myh6*)1Lnwd Location: unknown
• Alliance: Tg(Myh6*)1Lnwd page

Transgene origin

• Strain of Origin: (C57BL/6 x FVB/N)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6*)1Lnwd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Myh6 (29556)

  Myh6	(MGI:97255)

• Tg(Myh6*)1Lnwd expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Myh6 (29556)

  Myh6	(MGI:97255)

• Mutation details: Nucleotides 2,381 to 2,563 were deleted from published rat alpha-cardiac MHC and then fused to a COOH-terminal myc-tagged MHC fragment. This mutant cDNA was expressed under the control of a 3.3 kb of rat a-cardiac MHC promoter and the cDNA was followed by the mouse beta-globin terminator. The encoded protein lacks the light chain binding domain. (J:55938)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:55938 Welikson RE, et al., Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice. Am J Physiol. 1999 Jun;276(6 Pt 2):H2148-58
• All: 2 reference(s)