Tg(HBV-HCV)Kko
Transgene Detail

Summary

• Symbol: Tg(HBV-HCV)Kko
• Name: transgene insertion, Kazuhiko Koike
• MGI ID: MGI:3794557
• Transgene: Tg(HBV-HCV)Kko Location: unknown
• Alliance: Tg(HBV-HCV)Kko page

Transgene origin

• Strain of Origin: C57BL/6NJcl

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 0.6 kb fragment involving the HCV core protein was cloned downstream of HBV regulatory elements. 3-4 copies of the transgene were found in the original C21 founder. Transgene expression was detected in the liver, but not in the brain, salivary glands, lung, intestines, spleen or kidney. (J:94426)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(HBV-HCV)Kko

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:94426 Moriya K, et al., Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol. 1997 Jul;78(Pt 7):1527-31
• All: 10 reference(s)