Tg(HBB-cre)12Kpe
Transgene Detail

Summary

• Symbol: Tg(HBB-cre)12Kpe
• Name: transgene insertion 12, Kenneth Peterson
• MGI ID: MGI:3800816
• Synonyms: microLCR-betapr-Cre
• Transgene: Tg(HBB-cre)12Kpe Location: unknown
• Alliance: Tg(HBB-cre)12Kpe page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(HBB-cre)12Kpe expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  HBB (3043)

  Hbb-b1	(MGI:96021)
  Hbb-b2	(MGI:96022)
  Hbb-bh2	(MGI:96025)
  Hbb-bs	(MGI:5474852)
  Hbb-bt	(MGI:5474850)

• Mutation details: A transgenic construct containing the sequence encoding Cre recombinase under the control of the human beta hemoglobin (HBB) promoter, intron 2-enhancer fragment, and the human beta hemoglobin locus control region (LCR) was introduced into C57BL/6 donor eggs. Founder line 12 was established. Cre recombinase expression is detected in blood, brain, gonads, spleen and liver by RT-PCR analysis and in blood by RNAse protection assay. Recombination occurs at 50-100% efficiency in erythroid/megakarycytic cell lineages beginning at onset of hematopoiesis at approximately embryonic day 7.5. (J:89725, J:137519)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	HBB (human) Summary of all recombinase alleles driven by HBB. Comparative matrix view of recombinase activities Alliance human HBB gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:137519 Peterson KR, Generation of an erythroid-specific cre transgenic mouse. MGI Direct Data Submission. 2008
• All: 4 reference(s)