Tg(KRT5-TGFB1)F2020Xjw
Transgene Detail

Summary

• Symbol: Tg(KRT5-TGFB1)F2020Xjw
• Name: transgene insertion F2020, Xiao-Jing Wang
• MGI ID: MGI:3690994
• Synonyms: K5.hTGF-Beta1, K5.TGFbeta1^wt
• Transgene: Tg(KRT5-TGFB1)F2020Xjw Location: unknown
• Alliance: Tg(KRT5-TGFB1)F2020Xjw page

Transgene origin

• Strain of Origin: ICR X (C57BL/6 x DBA/2)

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-TGFB1)F2020Xjw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFB1 (7040)

  Tgfb1

  (MGI:98725)

• Tg(KRT5-TGFB1)F2020Xjw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: A human TGFB1 cDNA was placed under the control of the bovine KRT5 promoter. Two lines, F2020 and F2007 were produced. (J:90118)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:90118 Li AG, et al., Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J. 2004 Apr 21;23(8):1770-81
• All: 17 reference(s)