Tg(Ela1-Myc)158Bri
Transgene Detail

Summary

• Symbol: Tg(Ela1-Myc)158Bri
• Name: transgene insertion 158, Ralph L Brinster
• MGI ID: MGI:3511172
• Synonyms: 1194-2, Tg(Ela-1,Myc)Bri158
• Transgene: Tg(Ela1-Myc)158Bri Location: unknown
• Alliance: Tg(Ela1-Myc)158Bri page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ela1-Myc)158Bri expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myc (MGI:97250)

• Mutation details: 2.7 kb XbaI-XhoI fragment of murine Myc containing the entire protein coding region within exons 2 and 3 was placed under the regulation of the enhancer and promoter sequence of the rat elastase 1 gene. The human growth hormone gene Sma donated the 3'UTR and poly adenylation sequence in this construct. Transgene expression was detected in the pancreas. (J:76992)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ela1-Myc)158Bri

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:76992 Sandgren EP, et al., Pancreatic tumor pathogenesis reflects the causative genetic lesion. Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):93-7
• All: 2 reference(s)