Tg(H2-L-IL6)46Kish
Transgene Detail

Summary

• Symbol: Tg(H2-L-IL6)46Kish
• Name: transgene insertion 46, Tadamitsu Kishimoto
• MGI ID: MGI:3806463
• Synonyms: H2/huIL-6, L^d46, L^d-IL-6
• Transgene: Tg(H2-L-IL6)46Kish Location: unknown
• Alliance: Tg(H2-L-IL6)46Kish page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-L-IL6)46Kish expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL6 (3569)

  Il6	(MGI:96559)

• Mutation details: The transgene construct contained 1.4 Kb of the H2-L^d promoter driving expression of the human IL6 cDNA which had a 340 bp 3' untranlated region deleted, to increase mRNA stability. A 770 bp fragment of this construct was inserted into the rabbit beta-globin sequence, resulting in a 3.3 kb fragment which was injected into fertilized C57BL/6 eggs. (J:40405)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(H2-L-IL6)46Kish

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:40405 Suematsu S, et al., Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):232-5
• All: 7 reference(s)