Tg(Plp1-Nfasc*)1Brp
Transgene Detail

Summary

• Symbol: Tg(Plp1-Nfasc*)1Brp
• Name: transgene insertion 1, Peter J Brophy
• MGI ID: MGI:3808610
• Synonyms: Nfasc deltaIC
• Transgene: Tg(Plp1-Nfasc*)1Brp Location: unknown
• Alliance: Tg(Plp1-Nfasc*)1Brp page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Plp1-Nfasc*)1Brp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nfasc (MGI:104753)

• Mutation details: The promoter was used to drive expression of modified cDNA of Nfasc 155 that encoded amino acids 1 to 1073 (including the extracellular domain, transmembrane segment and only 13 of the 110 cytosolic amino acids) fused to a FLAG tag in oligodendrocytes and myelinating Schwann cells. A line with robust expression levels was used for further research. (J:107591)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:107591 Sherman DL, et al., Neurofascins are required to establish axonal domains for saltatory conduction. Neuron. 2005 Dec 8;48(5):737-42
• All: 2 reference(s)