Tg(RCAN1)M9Mapr
Transgene Detail

Summary

• Symbol: Tg(RCAN1)M9Mapr
• Name: Transgene insertion M9, Melanie A Pritchard
• MGI ID: MGI:3809545
• Synonyms: DSCR1-TG, RCAN1^ox, Tg(RCAN1)1Mapr
• Transgene: Tg(RCAN1)M9Mapr Location: unknown
• Alliance: Tg(RCAN1)M9Mapr page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(RCAN1)M9Mapr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RCAN1 (1827)

  Rcan1

  (MGI:1890564)

• Mutation details: A modified human RCAN1 cDNA containing 4kb of upstream sequence, exon 1, exons 5-7, and the 3'-UTR was constructed. Five transgenic founders were produced. Transgenic mice express about 4 times as much protein as wild-type controls. Results reported are primarily for line M9 although M1 is reported to give similar results. (J:132495)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:132495 Keating DJ, et al., DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease. Hum Mol Genet. 2008 Apr 1;17(7):1020-30
• All: 7 reference(s)