Tg(tetO-MET)23Rwng
Transgene Detail

Summary

• Symbol: Tg(tetO-MET)23Rwng
• Name: transgene insertion 23, Rong Wang
• MGI ID: MGI:3810467
• Synonyms: TRE-hMET, TRE-MET
• Transgene: Tg(tetO-MET)23Rwng Location: unknown
• Alliance: Tg(tetO-MET)23Rwng page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-MET)23Rwng expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MET (4233)

  Met	(MGI:96969)

• Mutation details: The TRE-MET transgene was designed with the human MET (met proto-oncogene (hepatocyte growth factor receptor)) coding sequence, under the control of heptamerized tetracycline operator (tetO; also called tetracycline-responsive element (TRE) or tet-operator) sequences and a cytomegalovirus (hCMV) minimal promoter with a beta-globin poly A signal. Founder line 23 was subsequently established. (J:69731)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:69731 Wang R, et al., Activation of the met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol. 2001 May 28;153(5):1023-34
• All: 4 reference(s)