Tg(Thy1-MAPT*)1Avil
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT*)1Avil
• Name: transgene insertion 1, J Avila
• MGI ID: MGI:3813500
• Synonyms: FTDP-17 human tau, tau^VLW
• Transgene: Tg(Thy1-MAPT*)1Avil Location: unknown
• Alliance: Tg(Thy1-MAPT*)1Avil page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT*)1Avil expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The promoter was used to drive neuron-specific expression of human MAPT with three point mutations that result in the following amino acid changes: G272V, P301L and R406W. These mutations have been identified in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). (J:73872)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:73872 Lim F, et al., FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Mol Cell Neurosci. 2001 Dec;18(6):702-14
• All: 15 reference(s)