Tg(MECP2)3Hzo
Transgene Detail

Summary

• Symbol: Tg(MECP2)3Hzo
• Name: transgene insertion 3, Huda Y Zoghbi
• MGI ID: MGI:3815541
• Synonyms: MeCP2^Tg3
• Transgene: Tg(MECP2)3Hzo Location: unknown
• Alliance: Tg(MECP2)3Hzo page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MECP2)3Hzo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MECP2 (4204)

  Mecp2

  (MGI:99918)

• Mutation details: A full-length copy of the human gene was injected into FVB fertilized oocytes. Line 3 (7-fold higher levels than endogenous Mecp2 protein) was established and maintained on an FVB background. (J:94407)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:94407 Collins AL, et al., Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum Mol Genet. 2004 Nov 1;13(21):2679-89
• All: 12 reference(s)