Tg(Myh11-icre/ERT2)1Soff
Transgene Detail

Summary

• Symbol: Tg(Myh11-icre/ERT2)1Soff
• Name: transgene insertion 1, Stefan Offermanns
• MGI ID: MGI:3819270
• Synonyms: Myh11-CreER^T2-Off, SMCCre, SMMHC-CreER^T2, Tg(Myh11-cre/ERT2)1Soff, Tg(Myh11-cre/ESR1)1Soff
• Transgene: Tg(Myh11-icre/ERT2)1Soff Location: unknown Genetic Position: ChrY, Syntenic
• Alliance: Tg(Myh11-icre/ERT2)1Soff page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Myh11-icre/ERT2)1Soff expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh11 (MGI:102643)

• Mutation details: The mouse promoter from BAC clone 26630 was used to drive inducible icre expression in smooth muscle cells. An frt-flanked beta-lactamase gene contained within the cre/ESR1 cassette was removed by flp mediated recombination prior to micro-injection into fertilized oocytes. No line information was given. (J:141641, J:148424)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myh11 (mouse) Summary of all recombinase alleles driven by Myh11. Comparative matrix view of recombinase activities Alliance mouse Myh11 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:141641 Wirth A, et al., G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med. 2008 Jan;14(1):64-8
• All: 276 reference(s)