Tg(Myh7-Ptpn11*Q79R)11Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh7-Ptpn11*Q79R)11Rbns
• Name: transgene insertion 11, Jeffrey Robbins
• MGI ID: MGI:3822132
• Synonyms: beta-MHC-Q97R11
• Transgene: Tg(Myh7-Ptpn11*Q79R)11Rbns Location: unknown
• Alliance: Tg(Myh7-Ptpn11*Q79R)11Rbns page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh7-Ptpn11*Q79R)11Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptpn11 (MGI:99511)

• Mutation details: The promoter was used to drive expression of Ptpn11 containing the amino acid substitution of arginine for glutamine at position 79 in the fetal heart. This mutation results in an increase in phosphatase activity. Several lines were created and line 11 was used in subsequent experiments. Line 14 expresses the transgene at lower levels than line 11. (J:123963)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:123963 Nakamura T, et al., Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. J Clin Invest. 2007 Aug;117(8):2123-32
• All: 1 reference(s)