Tg(CAG-cat,-Ptpn11*Q97R)1Rbns
Transgene Detail

Summary

• Symbol: Tg(CAG-cat,-Ptpn11*Q97R)1Rbns
• Name: transgene insertion 1, Jeffrey Robbins
• MGI ID: MGI:3822129
• Synonyms: CAGCAT-Q79R-Shp2
• Transgene: Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Location: unknown
• Alliance: Tg(CAG-cat,-Ptpn11*Q97R)1Rbns page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-cat,-Ptpn11*Q97R)1Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Ptpn11

• Mutation details: The ubiquitous CAG (chicken beta actin) promoter was used to drive cre-dependent expression of a modified Ptpn11 gene, which contains the amino acid substitution of arginine for glutamine at position 79, following removal of an intervening floxed chloramphenicol (cat) gene. The amino acid substitution results in an increase in phosphatase activity. Three lines were created and line 1 was used in subsequent experiments. (J:142212)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142212 Krenz M, et al., Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18930-5
• All: 3 reference(s)