Tg(RNU6-RNAi:Cldn16)551Dago
Transgene Detail

Summary

• Symbol: Tg(RNU6-RNAi:Cldn16)551Dago
• Name: transgene insertion 551, Daniel A Goodenough
• MGI ID: MGI:3822350
• Synonyms: pUG-U6-551, Tg(UBC-RNAi:Cldn16)551Dago
• Transgene: Tg(RNU6-RNAi:Cldn16)551Dago Location: unknown
• Alliance: Tg(RNU6-RNAi:Cldn16)551Dago page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Knockdown)
• Mutation: Insertion
• Tg(RNU6-RNAi:Cldn16)551Dago involves 1 genes/genome features (Cldn16) View all
• Mutation details: The human promoter was used to drive ubiquitous expression of GFP and a short hairpin RNA targeting Cldn16. Three lines were created (lines 453, 551 and 756) with line 756 exhibiting no knockdown effect with the other two lines down regulating transcript expression by greater than 100-fold as determined by real time quantitative RT-PCR. (J:122766)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:122766 Hou J, et al., Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium. J Biol Chem. 2007 Jun 8;282(23):17114-22
• All: 3 reference(s)