Tg(Ly6a-SET/NUP214)2969Gcg
Transgene Detail

Summary

• Symbol: Tg(Ly6a-SET/NUP214)2969Gcg
• Name: transgene insertion 2969, Gerard C Grosveld
• MGI ID: MGI:3822861
• Synonyms: SET-CAN
• Transgene: Tg(Ly6a-SET/NUP214)2969Gcg Location: unknown
• Alliance: Tg(Ly6a-SET/NUP214)2969Gcg page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ly6a-SET/NUP214)2969Gcg expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NUP214 (8021)

  Nup214

  (MGI:1095411)

  human

  SET (6418)

  Set	(MGI:1860267)

• Mutation details: The mouse promoter was used to drive early hematopoietic cell-specific expression of human SET intron 7-8 fused to NUP214 intron 17-18. This fusion mimics the human translocation t(9,9)(q32;34) identified in patients with acute undifferentiated leukemia. Three lines were created (2945, 2969, and 2971) with line 2969 selected as the representative line. (J:142938)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142938 Ozbek U, et al., SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. Am J Pathol. 2007 Aug;171(2):654-66
• All: 1 reference(s)